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When will it be legal here? |
Within 2 years |
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20% |
[ 3 ] |
2-5 years |
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13% |
[ 2 ] |
6-10 years |
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6% |
[ 1 ] |
11-20 years |
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26% |
[ 4 ] |
It'll never happen |
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33% |
[ 5 ] |
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Total Votes : 15 |
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K
Joined: 09 Sep 2011
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And WaPo:
https://www.washingtonpost.com/health/2019/03/06/biggest-advance-depression-years-fda-approves-novel-treatment-hardest-cases/
"The label for the drug will carry a black box warning the most serious safety warning issued by the FDA. It will caution users they could experience sedation and problems with attention, judgment and thinking, and that theres potential for abuse and suicidal thoughts. ...
The medicine has a complex legacy because it is a component of ketamine, which was approved years ago as an anesthetic and was once popular as a party drug...
The company opted for a nasal spray after concluding that IV administration was impractical and a pill wouldnt get enough of the drug to the brain, according to David Hough, the esketamine team leader at Janssen Research & Development, which is part of Johnson & Johnson.
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Older antidepressants target the neurotransmitters serotonin, norepinephrine or dopamine. Esketamine affects the receptor for a different brain chemical called glutamate." |
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K
Joined: 09 Sep 2011
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Seven Buds for Seven Brothers
This leading CBD company is a family affair.
https://www.nytimes.com/2019/03/06/style/cbd-charlottes-web-seven-brothers.html
"Charlottes Web, a leading purveyor of the substance the Uber of CBD, if you will...
"They crossbred multiple varieties to get one that contained 22 percent and named the products derived from it after their first patient, Charlotte, a little girl with Dravet syndrome, a very rare and destructive form of epilepsy that caused her to have hundreds of seizures.
The brothers were still focused on medical marijuana as a business, but that changed in August 2013 when CNNs Sanjay Gupta did a special on their success with Charlotte. Fifteen thousand families reached out to them in the next month, they said, and the company decided to focus on CBD. Charlottes Web was born.
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"Since the beginning of 2018, Charlottes Web has experienced a 60 percent growth in sales online. The product is now found in 3,700 stores across the United States. The company is forecasting revenue growth of $120 to $170 million in 2019, up from $15 million in 2016." |
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K
Joined: 09 Sep 2011
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Lyrica, Pfizer, and how big pharma gets what it wants
https://www.theage.com.au/national/lyrica-pfizer-and-how-big-pharma-gets-what-it-wants-20190211-p50x1z.html
"More than 4 million scripts for pregabalin, the drugâs generic name, were written in 2017-18, costing government and consumers more than $171 million.
Thatâs come with a huge toll. An investigation by The Age revealed Pfizerâs âsafe, non-addictiveâ nerve-pain pill was highly addictive, dangerous when taken with other drugs, and came with a range of nasty side-effects - including suicidal thoughts.
The drug has been linked to more than 250 drug overdose deaths and six suicides. More than 85,000 Australians are abusing pregabalin, according to one study. Concerned doctors are scrambling to deal with the fallout.
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An investigation by The Sunday Age and The Sun-Herald has uncovered a sophisticated and well-funded effort by Pfizer to win government subsidy for the drug then promote it to doctors and consumers.
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None of Pfizerâs actions are illegal. But the investigation reveals the enormous influence pharmaceutical companies like Pfizer can have.
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Health consumer organisations are meant to represent the interests of patients, lobby for funding for conditions, and fight for new drugs to be made available.
But many accept significant donations from pharmaceutical companies, putting them at risk of a conflict of interest.
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âIt was part of their marketing strategy. They wouldnât have done it otherwise. Why would they do it otherwise?"
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"Self-interest drives these companies, and profit, let's not kid ourselves."
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US studies have found when a pharma company âeducatesâ doctors about a drug, they tend to prescribe more of it, and do a worse job of making sure they are giving it for the right indications.
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In LinkedIn posts, several Pfizer sales representatives brag about their successes selling Lyrica and getting it onto hospital "formularies" - the hospital's stock of default drugs.
"I successfully achieved Lyrica formulary listings in the following hospitals by getting local Specialists to champion the listing," said one. "I know what it takes to get formulary of your product portfolio."
That salesman also boasted that he specialised in "GP surgery lunch meetings". "Lyrica PBS listing March 2012 with growth over 500%," he wrote." |
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K
Joined: 09 Sep 2011
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^^^
https://www.racgp.org.au/afp/2014/october/changes-in-mood,-depression-and-suicidal-ideation-after-commencing-pregabalin-for-neuropathic-pain/
"The product information for pregabalin (Lyrica) states that âpatients treated with any AED [anti-epileptic drug] for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behaviour, and/or any unusual changes in mood or behaviourâ. It also states that when compared with placebo the increased incidence of suicidal behaviour or ideation for patients treated with anti-epileptic drugs was approximately one case per 530 patients. Here we report five cases of suicidal thoughts or increased depression from the first 50 (approximately) patients commencing pregabalin at the Gold Coast Interdisciplinary Persistent Pain Centre (GCIPPC) after it was listed on the Pharmaceutical Benefits Scheme (PBS) on 1 March 2013 for the management of persistent neuropathic pain."
Great, huh? You take a PBS drug for back pain and end up suiciding... I think I'd prefer pot for pain relief than Lyrica. |
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K
Joined: 09 Sep 2011
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Purdue Pharma and Sacklers Reach $275 Million Settlement in Opioid Lawsuit
https://www.nytimes.com/2019/03/26/health/opioids-purdue-pharma-oklahoma.html
"But the settlement also means that the public will not hear a full recounting of Purdueâs actions in promoting OxyContin to doctors and underplaying its addictive properties, including testimony by members of the Sackler family." |
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Skids
Quitting drinking will be one of the best choices you make in your life.
Joined: 11 Sep 2007 Location: Joined 3/6/02 . Member #175
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All of these; highly addictive & legal substances could be replaced with a simple spliff.
I was prescribed Valium & an anti-inflammatory a few years ago when I injured my back. Sure, they worked, but the valium made me even more dopey than I already am and the anti inflammatory played havoc with my stomach.
Some good weed worked just as well, the only side effects being, the overconsumption of; Tim Tams, Drumsticks and chocolate bars, along with restful nights sleep.
Has anyone ever had an OxyContin? I have on 2 occasions (i'll try anything once... or twice ) ... talk about wasted!! That is some powerful shit! _________________ Don't count the days, make the days count. |
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Wokko
Come and take it.
Joined: 04 Oct 2005
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I had Endone (Oxy) recently for a torn tendon in my shoulder; when the pain's bad enough the high isn't that great. |
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K
Joined: 09 Sep 2011
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And is it more effective for pain relief than other stuff? |
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K
Joined: 09 Sep 2011
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Ralph Metzner, LSD and Consciousness Researcher, Dies at 82
https://www.nytimes.com/2019/04/04/obituaries/ralph-metzner-dead.html
'Dr. Metzner ... was a graduate student there when he began working with Dr. Leary and Richard Alpert, who were clinical psychology professors and had begun exploring therapeutic and other uses for LSD, psilocybin and similar hallucinogens. The three later collaborated on âThe Psychedelic Experience: A Manual Based on the Tibetan Book of the Deadâ (1964), one of the core texts of the emerging psychedelic movement.
Dr. Leary and Dr. Alpert (who later took the name Ram Dass) were both dismissed from Harvard in 1963 amid revelations that they had given hallucinogens to undergraduates as part of their research.
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Among his recent interests was whether some drugs that have been demonized, like MDMA (commonly known as Ecstasy), might be useful in treating post-traumatic stress disorder or in end-of-life care.
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âActually, your consciousness expands every morning when you wake up,â he explained in the 2015 interview. âYouâre coming out of a dream and you say, âOh, hereâs my room, my bed, my wife, my family, my dog, my job.â Thatâs a series of consciousness expansions. And every night when you go to sleep you kind of close in. And thatâs a perfectly normal thing, to expand consciousness and to also be able to contract consciousness and focus.â
âThe ideal,â he added, âis to have them be under your intentional control.â ' |
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Wokko
Come and take it.
Joined: 04 Oct 2005
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K wrote: | And is it more effective for pain relief than other stuff? |
Yeah, it's pretty good. But it's the next step up from codeine which is pretty useless for me. |
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K
Joined: 09 Sep 2011
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Doctors Accused of Trading Opioid Prescriptions for Sex and Cash
https://www.nytimes.com/2019/04/17/us/doctor-arrested-prescription-drugs.html
'Opioid prescriptions were exchanged for sex in some cases, and for cash with an added âconcierge feeâ in others. One doctor was accused of routinely prescribing opioids to friends on Facebook.
Prosecutors said the doctor in northern Alabama ârecruited prostitutes and other young women with whom he had sexual relationshipsâ to become his patients. He also opened his home to people using heroin, methamphetamine, cocaine and marijuana, they said, in a criminal complaint, adding that police officers had been to the house several times concerning overdoses and other complaints.
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The indictments accuse 60 people, including 31 doctors, seven pharmacists and eight nurses, of involvement in the schemes, which included prescribing opioids for gratuitous medical procedures like unnecessary tooth pulling. In some cases, prosecutors said, doctors simply handed out signed blank prescription forms.
âThese cases involve approximately 350,000 opioid prescriptions and more than 32 million pills..." ' |
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K
Joined: 09 Sep 2011
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Cannabis, Marijuana, Weed, Pot? Just Call It a Job Machine
https://www.nytimes.com/2019/04/25/business/economy/jobs-in-cannabis-weed-marijuana.html
"Although cannabis remains illegal on the federal level, 33 states now allow its sale at least for medical purposes. Ten of them, including California, have legalized recreational use. And as new markets open and capital continues to flood in, the cannabis industry has become, by some measures, one of the countryâs fastest-growing job sectors.
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Julia Pollak, a labor economist at ZipRecruiter, said the companyâs data put the number of cannabis jobs nationwide at 200,000 to 300,000. Most of those jobs are on the lower end of the pay scale, consisting of rote agricultural work like plant trimming ($10 to $15 an hour) and âbudtendersâ (about $25,000 a year), who help customers decide what kind of cannabis they want and then weigh and bag it.
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Ms. Azer projects that the legal United States cannabis market will grow to $80 billion by 2030, a forecast that assumes federal legalization.
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Eager to shake the image of being high-end drug dealers, cannabis companies have become hypersensitive to anything that sounds unprofessional â hence the insistence on calling the substance cannabis instead of pot, weed or marijuana. Buds are âflower.â Hash is âextract.â " |
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K
Joined: 09 Sep 2011
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In Washington, Juul Vows to Curb Youth Vaping. Its Lobbying in States Runs Counter to That Pledge.
https://www.nytimes.com/2019/04/28/health/juul-lobbying-states-ecigarettes.html
"For months, Juul Labs has had a clear, unwavering message for officials in Washington: The e-cigarette giant is committed to doing all it can to keep its hugely popular vaping products away from teenagers.
But here in Columbia, the South Carolina capital, and in statehouses and city halls across the country, a vast, new army of Juul lobbyists is aggressively pushing measures that undermine that pledge.
The companyâs 80-plus lobbyists in 50 states are fighting proposals to ban flavored e-cigarette pods, which are big draws for teenagers; pushing legislation that includes provisions denying local governments the right to adopt strict vaping controls; and working to make sure that bills to discourage youth vaping do not have stringent enforcement measures." |
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K
Joined: 09 Sep 2011
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CBD Is Wildly Popular. Disputes Over Its Legality Are a Growing Source of Tension.
https://www.nytimes.com/2019/05/06/us/cbd-cannabis-marijuana-hemp.html
"But while CBD is now as common as coffee in some neighborhoods, sold in shopping malls and tested by a national hamburger chain, possession of CBD in some places can prompt an arrest.
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Confusion over CBD dates back years, but it intensified last year when a provision of the 2018 Farm Bill lifted a federal ban on hemp production that had previously classified hemp as a controlled substance on a par with heroin.
Marijuana is rich in THC, or tetrahydrocannabinol, the psychoactive component; it can account for as much as 40 percent of the total cannabinoid content. Hemp, on the other hand, is richer in CBD, and generally contains only 0.3 percent THC or less. CBD oils, which are processed from the hemp plant, are legal to possess under the new federal law as long as they, too, contain no more than 0.3 percent THC.
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Though now legal under federal law, CBD is still subject to regulation when it is sold with a claim of therapeutic benefit. Federal policy maintains that adding CBD oil to food products is the same as adding a prescription drug â in other words, forbidden without a doctorâs prescription. But states and cities have made their own rules on the issue, creating up a dizzying, sometimes contradictory patchwork of regulations for consumers, who also have few rigorous scientific trials or studies to rely on about the productâs true effects and limitations.
Both hemp and marijuana are varieties of the cannabis plant, which is believed to have been among the first plants that humans cultivated. The plants produce a family of chemicals known as cannabinoids, some of which are psychoactive â meaning they produce a high when smoked or ingested â while others are not. A major difference between marijuana and hemp lies in how much of each they produce." |
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Skids
Quitting drinking will be one of the best choices you make in your life.
Joined: 11 Sep 2007 Location: Joined 3/6/02 . Member #175
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Get on I reckon....
Cannabis stocks on the ASX: The Ultimate Guide
As clinical research on its medical benefits ramp up and its commercial uses are explored, this could mean an opportune time to invest â or will it just be a flash in a pan?
Why was it made illegal?
Cannabis was a key ingredient in many mass-produced legal drugs in the early 1900s before restrictions increased and it began being labelled as a poison.
Two American men have been marked as the culprits for the modern prohibition of marijuana: Harry Anslinger and William Randolph Hearst.
Anslinger became the Director of the Federal Bureau of Narcotics in 1930 and Hearst, a publishing and timber mogul, was considered his co-conspirator.
In 1936, the US propaganda film Reefer Madness was released, telling the cautionary tale of teenagers who were enticed by drug dealers to smoke âreeferâ (cannabis) cigarettes and consequently, lead a life of horrendous crime.
It demonised marijuana as a dangerous drug and played on the racist attitudes of white Americans at the time, mirroring Anslingerâs campaigns depicting African-Americans as being more disposed to the drug and pushing it on innocent white people, along with their âSatanicâ jazz music.
Meanwhile, Hearst lost 800,000 acres of timberland to Pancho Villa during the Mexican Revolution, plus his paper mills were increasingly being replaced by hemp.
So, he took advantage of his publishing empire to taint public perception of marijuana by linking it to the Mexicans.
In fact, the Mexican Spanish word âmarihuanaâ was used instead of cannabis in propaganda, further elevating the discomfort levels of Americans who feared the influx of Mexican immigrants in the southern states, particularly Texas and Louisiana.
Another reason cannabis was disliked was because people could grow it themselves, which impacted pharmaceutical and petrochemical companies.
The DuPont chemical company had a financial interest in stamping out hemp production as it began selling rayon, and then nylon, fibre in the 1920s and 1930s.
As Anslinger and Hearstâs smear campaign continued, cannabis was regulated in every state of the US by the mid-1930s.
Then the Marijuana Tax Act of 1937 was enacted, which effectively banned the use and sale of marijuana. Anslinger was the author of this legislation.
This act was later replaced by the Controlled Substances Act of 1970, which placed cannabis on the most restricted drug use, Schedule 1, making it very hard to legally obtain for drug manufacturers and even researchers.
This restrictive drug status spread to most modern Western countries so there was little or no modern pharmacological research into the hundreds of natural compounds, including 104 cannabinoids, that are found in the cannabis plant.
It is only now that we are finding out in greater detail how these various cannabinoid compounds interact and trigger receptors in the central nervous and immune system to produce effects that may be highly beneficial to human health.
https://smallcaps.com.au/cannabis-stocks-asx-ultimate-guide/ |
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